Michael Calore: Is there a distinction between how a lot weight males lose on these medication and ladies lose on them?
Emily Mullin: Yeah. So I am glad you pointed that out, as a result of that does appear to be one of many indicators that folks reply in another way to those medication. And what a few of the scientific trials are displaying is that ladies, for no matter motive, appear to lose extra weight than males on these medication. So one doable motive is that ladies simply have a special fats composition than males. Another excuse is that ladies, on common, are smaller than males, and so if you’re taking the identical quantity of a drug, and it has much less locations to go within the physique, it is possibly more practical than anyone who is greater and has extra weight on them.
Michael Calore: I see. So you may’t simply take the drug and lose a bunch of weight with out additionally making another life-style adjustments, proper?
Emily Mullin: Yeah, precisely. So in scientific trials of semaglutide and tirzepatide, simply in order that listeners are conscious, semaglutide, we’re speaking about Ozempic and WeGovy, and tirzepatide, speaking about Mounjaro and ZepBound, these model names. So in scientific trials, after all, these are very rigorously designed, and individuals are taking these medication alongside a really prescribed eating regimen and train plan. So these are the best circumstances of taking this drug. And naturally, in actual life folks won’t be following that fairly as nicely. And one other factor is, one of many specialists I talked to, an endocrinologist, she very astutely identified that there are lots of completely different the explanation why we eat. We do not simply eat as a result of we’re hungry, we eat as a result of it is a very social factor. And so in case you are a kind of people who find themselves in lots of conditions the place there are social temptations to exit and eat socially, or we eat simply because the meals tastes good. I feel we are able to all relate to consuming ice cream out of a bathtub or ending off a bag of chips, not as a result of we are literally hungry, however as a result of it simply tastes good.
Michael Calore: I eat as a result of I am unhappy or indignant.
Emily Mullin: Perhaps that is a dialogue for an additional podcast episode.
Kate Knibbs: I’ve a query, Emily, for you. Have you ever talked to any researchers who’ve been learning the variations in outcomes between people who find themselves taking model title Ozempic or ZepBound, et cetera, and people who find themselves taking compounded meds? As a result of that is one thing that I have been looking for out, and I have not discovered anybody who’s learning that but.
Emily Mullin: Yeah, I have not run throughout that.
Michael Calore: Is anyone doing any analysis in any respect about any of the compound medication, like their security or the composition of them?
Kate Knibbs: Yeah, I have been looking for research which might be particularly trying on the compounded variations, and it is actually exhausting. A variety of the extra well-established telehealth clinics may have their very own lab work accomplished, and a few of them will share it, however impartial researchers, I do not know. If any of them are listening, I extremely encourage them to do it, as a result of … And once more, that is completely anecdotally, however of all the those that I do know on GLP-1 meds, the bulk are on compounded medicines.
